Adeno‐associated viral vectors encoding anti‐P2X7 nanobodies reduce graft‐versus‐host disease in a humanised mouse model
This study indicates that P2X7 blockade with an anti-m/hP2X7 and to a lesser extent an anti-mP2X7 Nb reduces GVHD progression in humanised mice. This supports the future testing of these P2X7 biologics as a prophylactic therapy for GVHD.
Authors
- Debbie Watson (ORCID: https://orcid.org/0000-0002-6242-3944)
- Sahil Adriouch (ORCID: https://orcid.org/0000-0002-0265-7773)
- Amal Elhage (ORCID: https://orcid.org/0000-0003-0625-3183)
- Ronald Sluyter (ORCID: https://orcid.org/0000-0003-4909-686X)
- Chloe Sligar (ORCID: https://orcid.org/0000-0002-9214-0742)
- Janna H Hadaya (ORCID: https://orcid.org/0009-0003-4426-0445)
Institutions
- Inserm (FR)
- University of Wollongong (AU)
- Normandie Université (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/cti2.70061
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Australian Government
- Agence Nationale de la Recherche
- University of Wollongong
- Precursory Research for Embryonic Science and Technology