Therapeutic efficacy of WS2 nanosheets combined with CT-guided microwave ablation in rabbit VX2 liver tumor model
Computed tomography (CT)-guided percutaneous microwave ablation (MWA) serves as a standard approach for hepatocellular carcinoma (HCC) treatment, yet faces challenges of higher recurrence rates when treating tumors in special anatomical locations. This study evaluated tungsten disulfide (WS<sub>2</sub>) nanosheets combined with CT-guided MWA for treating rabbit VX2 liver tumors. WS<sub>2</sub> nanosheets were synthesized and demonstrated excellent microwave thermal effects and CT imaging capability <i>in vitro</i>. In animal studies, the combination therapy significantly enhanced tumor necrosis and apoptosis rates compared to MWA alone, while also activating systemic antitumor immunity as evidenced by increased cytotoxic T lymphocyte (CD8<sup>+</sup> T cell) infiltration. The findings suggest WS<sub>2</sub> nanosheets improve MWA efficacy through enhanced energy absorption and immune activation, offering a promising combinatorial strategy for HCC treatment.
Authors
- Yi Xie (ORCID: https://orcid.org/0000-0002-2641-5859)
- Yu Hui
- Mingzhu Lv
- Xiaoxue Xu (ORCID: https://orcid.org/0000-0002-2598-3766)
- Chuan Zhang (ORCID: https://orcid.org/0000-0003-4621-9780)
- Bing Li (ORCID: https://orcid.org/0000-0002-7896-7903)
- Shan He
- Yuan Yong (ORCID: https://orcid.org/0000-0002-0890-3218)
- Hanfeng Yang
- Haiyan Jiang (ORCID: https://orcid.org/0000-0002-0073-9150)
Institutions
- North Sichuan Medical University (CN)
- State Ethnic Affairs Commission (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Southwest Minzu University (CN)
Publication Details
- Journal
- iScience
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.isci.2025.113971
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00