A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density
Our study demonstrates that the observed association between CAC and eBMD is mainly driven by pleiotropic associations.
Authors
- Bin Yang (ORCID: https://orcid.org/0000-0001-7948-3823)
- Douglas P. Kiel (ORCID: https://orcid.org/0000-0001-8474-0310)
- Sirui Zheng
- Xunying Zhao (ORCID: https://orcid.org/0000-0002-6754-9773)
- Xia Jiang (ORCID: https://orcid.org/0000-0001-5878-8986)
- Bowen Lei (ORCID: https://orcid.org/0000-0003-4980-6702)
- Xin Song (ORCID: https://orcid.org/0000-0001-5263-5698)
- Mingzhu Xia (ORCID: https://orcid.org/0000-0001-7533-6535)
- Tao Han (ORCID: https://orcid.org/0000-0003-4216-6968)
- Jiaojiao Hou
- Jinyu Zhou (ORCID: https://orcid.org/0009-0003-3346-4805)
- Jiangbo Zhu (ORCID: https://orcid.org/0000-0002-1400-2854)
- Qin Deng
- Yang Qu (ORCID: https://orcid.org/0009-0006-7485-959X)
- Y. C. Zhong
- Rong Xiang
- Linna Sha (ORCID: https://orcid.org/0009-0005-7117-8804)
- Ting Yu
Institutions
- Beth Israel Deaconess Medical Center (US)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Hebrew SeniorLife (US)
Publication Details
- Journal
- Bone
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.bone.2025.117719
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00