First-in-Human, Phase I/II Dose Escalation and Expansion Study of Zelenectide Pevedotin in Patients With Advanced Solid Tumors: Results From Monotherapy Dose Escalation
Zelenectide pevedotin monotherapy demonstrated a generally well-tolerated safety profile and preliminary efficacy, particularly in UC, supporting investigation of UC and non-UC populations in the expansion phase.
Authors
- Meredith McKean (ORCID: https://orcid.org/0000-0003-0944-7418)
- Elisa Fontana (ORCID: https://orcid.org/0000-0002-4991-9355)
- Rajiv Sharma (ORCID: https://orcid.org/0009-0004-9144-7402)
- Amy L. Dickson
- Júlia Lostes
- Òscar Reig (ORCID: https://orcid.org/0000-0003-1166-6943)
- Capucine Baldini (ORCID: https://orcid.org/0000-0002-0604-7614)
- Bernard Doger de Spéville (ORCID: https://orcid.org/0009-0004-3264-5433)
- Jordi Rodón (ORCID: https://orcid.org/0000-0001-6467-3632)
- Carly Campbell (ORCID: https://orcid.org/0000-0002-7600-3027)
- Louise Carter (ORCID: https://orcid.org/0000-0002-9854-2304)
- Vincent Goldschmidt (ORCID: https://orcid.org/0000-0002-2053-8639)
- Jason Robert Brown (ORCID: https://orcid.org/0000-0001-6225-7555)
- Antoîne Italiano (ORCID: https://orcid.org/0000-0002-8540-5351)
- Justin Bader
- Gerald S. Falchook (ORCID: https://orcid.org/0000-0001-9165-2191)
- Loïc Verlingue (ORCID: https://orcid.org/0000-0002-5694-4022)
- Kate Josephs (ORCID: https://orcid.org/0009-0009-4582-9561)
- Leslie R. DeMars
- Andrea Necchi (ORCID: https://orcid.org/0000-0002-3007-2756)
- Cong Xu (ORCID: https://orcid.org/0000-0002-9571-326X)
- Sophie Cousin (ORCID: https://orcid.org/0000-0002-4847-6329)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Université de Bordeaux (FR)
- Vita-Salute San Raffaele University (IT)
- Sarah Cannon Research Institute (GB)
- Breast Cancer Research Foundation (US)
- Institut Gustave Roussy (FR)
- University of Manchester (GB)
- Sarah Cannon (US)
- Centre Léon Bérard (FR)
- University Hospitals Seidman Cancer Center (US)
- HealthONE (US)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- IRCCS Ospedale San Raffaele (IT)
- The Christie NHS Foundation Trust (GB)
- Institut Bergonié (FR)
- Bicycle Therapeutics (United Kingdom) (GB)
- Vall d'Hebron Institute of Oncology (ES)
- Case Western Reserve University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1200/jco-25-00559
- Citations
- 2
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.61