The modulatory role of GABA in the triple network and its impact on anhedonia and cognitive function in depression
Female patients with MDD exhibit a specific reduction in GABA levels in the left DLPFC. Furthermore, these lower GABA levels are associated with increased anhedonia and poorer executive function. Critically, the neurochemical coupling between GABA and large-scale brain networks is also disrupted in MDD.
Authors
- Zhijian Yao (ORCID: https://orcid.org/0000-0001-6255-5771)
- Yingying Huang (ORCID: https://orcid.org/0009-0007-0492-2116)
- Mengmeng Zhang (ORCID: https://orcid.org/0000-0003-2745-0995)
- Rui Yan (ORCID: https://orcid.org/0000-0002-8495-1289)
- Qing Lü (ORCID: https://orcid.org/0000-0001-7717-391X)
- Qinghua Zhai (ORCID: https://orcid.org/0000-0003-2879-356X)
- Wenyue Gong
- Yiwen Wang (ORCID: https://orcid.org/0000-0002-7594-1396)
- Azi Shen
Institutions
- Nanjing Brain Hospital (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- NeuroImage
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.neuroimage.2025.121567
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00