Cancer risks for MSH6 pathogenic variant carriers
These refined, age- and sex-specific risk estimates for MSH6 PV carriers inform tailored surveillance strategies, supporting delayed CRC screening and individualised counselling on risk-reducing surgery for women.
Authors
- E. Gómez (ORCID: https://orcid.org/0000-0003-4999-8847)
- A. Lam (ORCID: https://orcid.org/0000-0001-5731-7146)
- A. Bakker (ORCID: https://orcid.org/0000-0001-7852-9332)
- Ellis L. Eikenboom
- Floor A.M. Duijkers (ORCID: https://orcid.org/0000-0001-8165-1662)
- Maartje Nielsen (ORCID: https://orcid.org/0000-0002-5351-1870)
- Aung Ko Win (ORCID: https://orcid.org/0000-0002-2794-5261)
- Fonnet E. Bleeker (ORCID: https://orcid.org/0000-0002-9337-6909)
- Sanne W. ten Broeke (ORCID: https://orcid.org/0000-0001-6280-0087)
- Tom G.W. Letteboer
- Mark A. Jenkins (ORCID: https://orcid.org/0000-0002-8964-6160)
- Liselotte P. van Hest (ORCID: https://orcid.org/0000-0002-9373-6601)
- Anja Wagner (ORCID: https://orcid.org/0000-0001-7431-3876)
- Mirjam M. de Jong
- Christi J. van Asperen
- James G. Dowty
- Gilles Thomas (ORCID: https://orcid.org/0000-0003-4526-298X)
- Claire C.A. Cornips (ORCID: https://orcid.org/0009-0005-4683-9076)
- Morrison Italia
- Fernande C.H.A. Koops (ORCID: https://orcid.org/0009-0004-9189-8975)
Institutions
- Leiden University (NL)
- University Medical Center Groningen (NL)
- The University of Melbourne (AU)
- University of Groningen (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.ejca.2025.116098
- Citations
- 3
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Vanderbilt University Medical Center
- Maag Lever Darm Stichting