Axin-1, modified by IGF2BP2-dependent m6A, triggers neuronal ferroptosis in delayed encephalopathy animal model caused by carbon monoxide poisoning via Smurf1-mediated BDNF ubiquitination
IGF2BP2-mediated m<sup>6</sup>A modification of Axin-1 promoted oxidative damage and neuronal ferroptosis by modulating Smurf1/BDNF and Nrf2/HO-1 pathways in DEACMP animal model and OGD/R cell model. Therefire, Axin-1 may be a potential therapeutic target for the treatment of DEACMP.
Authors
- Yingbo Wang (ORCID: https://orcid.org/0000-0002-5602-5616)
- Jiming Han (ORCID: https://orcid.org/0000-0003-0026-3241)
- Shaokun Wang (ORCID: https://orcid.org/0009-0002-1685-1945)
- Li Pang (ORCID: https://orcid.org/0000-0002-3952-937X)
- Nan Gao (ORCID: https://orcid.org/0000-0001-7700-1544)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111624
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00