Multi-omics analysis reveals gut microbial and metabolic signatures in metabolic dysfunction-associated steatotic liver disease
After analysis of gut microbiota and metabolites, we found that <i>Lactobacillus johnsonii</i> down-regulated in MASLD drives 2,6-Dichlorohydroquinone accumulation, provoking toxic buildup and accelerating disease progression.
Authors
- Xing-Fu Wang (ORCID: https://orcid.org/0000-0002-6592-6547)
- Yanfang Guan (ORCID: https://orcid.org/0000-0002-6722-2615)
- Muyesaier Maimaitiyiming
- Abula Abuduaini
- Yierpan Aishan
- Sulitanguli Maihemuti
- Tangnuer Aierken
- Gulizhati Abulimiti
- Tuersinayi Aibaidula
- Abudoukeyoumu Simayi
- Maiwulan Aimaiti
Institutions
- Kashi University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fmicb.2025.1666110
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Xinjiang