Sex-stratified pharmacovigilance of gastrointestinal events associated with first-line smoking-cessation medicines: Insights from the FAERS database
NRT, varenicline, and bupropion exhibit distinct and statistically significant sex-specific GI AE reporting profiles in a real-world setting. These hypothesis-generating findings underscore the importance of considering sex as a variable in pharmacovigilance studies and may inform future research aimed at personalizing smoking cessation therapy.
Authors
- Xiao-Xuan Wu (ORCID: https://orcid.org/0000-0001-9800-2490)
- Junyou Chen
- Ziyan Wang (ORCID: https://orcid.org/0000-0003-2017-1993)
- Haoxiong Sun (ORCID: https://orcid.org/0009-0000-6570-0890)
Institutions
- Uppsala University (SE)
- Monash Health (AU)
- University College London (GB)
- Imperial College London (GB)
- Monash University (AU)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1371/journal.pone.0336021
- Citations
- 1
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.31