Substituted cysteine modification and protection indicates selective interactions of the anesthetic photolabel pTFD-di-iPr-BnOH with α+/β– and α+/γ– transmembrane subunit interfaces of synaptic GABAA receptors
SCAMP results further support the hypothesis that pTFD-di-iPr-BnOH binds selectively in α+/β- and α+/γ- interfacial sites that are homologs of the β+/α- etomidate sites.
Authors
- Stuart A. Forman (ORCID: https://orcid.org/0000-0001-6340-2478)
- Kieran Bhave (ORCID: https://orcid.org/0000-0002-8023-5525)
Institutions
- Massachusetts General Hospital (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1371/journal.pone.0336606
- Primary Topic
- Photochromic and Fluorescence Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00