Leukocytic ADAM10 and ADAM17 modulate disease severity and systemic outcome in bacterial and viral pneumonia
Leukocytic ADAM10 and ADAM17 and their release on exosomes may constitute relevant regulatory elements in bacterial and viral pneumonia, with a potential contribution of exosomes to disease progression and systemic inflammatory responses. Therefore, the diagnostic, prognostic and therapeutic value of ADAM10 and ADAM17 should be evaluated in further preclinical and translational studies, addressing the changes of the immune response and exosomes as cargo vehicles both at local site and for the prevention of systemic effects.
Authors
- Claus‐Michael Lehr (ORCID: https://orcid.org/0000-0002-5864-8462)
- Christoph Beißwenger (ORCID: https://orcid.org/0000-0003-4391-3240)
- Xiao Yu Tian (ORCID: https://orcid.org/0000-0003-3472-9898)
- Matthias W. Laschke (ORCID: https://orcid.org/0000-0002-7847-8456)
- Matthias Hannig (ORCID: https://orcid.org/0000-0003-0669-6881)
- Markus Bischoff (ORCID: https://orcid.org/0000-0001-6734-2732)
- Ulrich Boehm (ORCID: https://orcid.org/0000-0003-2436-6907)
- Ahmad Aljohmani (ORCID: https://orcid.org/0000-0003-0982-3583)
- Oliver Schilling (ORCID: https://orcid.org/0000-0001-7678-7653)
- Robert Bals (ORCID: https://orcid.org/0000-0002-1472-9535)
- Philipp Wartenberg
- Daniela Yildiz (ORCID: https://orcid.org/0000-0002-9702-8581)
- Linda Pätzold
- Martin Witzenrath
- Christian Herr
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Humboldt-Universität zu Berlin (DE)
- Helmholtz Centre for Infection Research (DE)
- Institute of Medical Microbiology and Hygiene (DE)
- Helmholtz Institute for Pharmaceutical Research Saarland (DE)
- Saarland University (DE)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1183/13993003.02060-2024
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81