Prognostic value of disease severity and mechanical ventilation intensity in acute respiratory distress syndrome: analysis of the LUNG SAFE cohort
Normalised elastance, DP and 4DP+RR, measured at day 1 of ARDS, were the best predictors of ICU mortality, and outperformed oxygenation and MP. DP showed the best balance between predictive accuracy and clinical simplicity. These results reinforce the importance of focusing on DP and 4DP+RR as key metrics to guide lung-protective strategies and ARDS severity classification.
Authors
- Emanuele Rezoagli (ORCID: https://orcid.org/0000-0002-4506-7212)
- Giacomo Bellani (ORCID: https://orcid.org/0000-0002-3089-205X)
- Alessandro Protti (ORCID: https://orcid.org/0000-0002-0172-6079)
- Antonio Artigas (ORCID: https://orcid.org/0000-0002-8029-1017)
- Fabiana Madotto (ORCID: https://orcid.org/0000-0002-8829-9160)
- Tài Pham (ORCID: https://orcid.org/0000-0002-4373-0711)
- Laurent Brochard (ORCID: https://orcid.org/0000-0002-7456-906X)
- John G. Laffey (ORCID: https://orcid.org/0000-0002-1246-9573)
Institutions
- Université Paris-Sud (FR)
- St. Michael's Hospital (CA)
- Humanitas University (IT)
- Inserm (FR)
- Science Foundation Ireland (IE)
- University of Toronto (CA)
- Ollscoil na Gaillimhe – University of Galway (IE)
- University of Milan (IT)
- University of Trento (IT)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- University Hospital Galway (IE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Santa Chiara (IT)
- Health First (US)
- MultiMedica (IT)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Azienda Ospedaliera San Gerardo (IT)
- ASV (United States) (US)
- Nini Hospital (LB)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Bicêtre Hospital (FR)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1183/13993003.00742-2025
- Citations
- 8
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 12.15