Consensus on the management of refractory nontuberculous mycobacterial pulmonary disease
This study offers a structured approach to managing treatment failure in NTM-PD, addressing patient selection, treatment intensification, de-escalation and supportive care, while championing individualised strategies. Future research should concentrate on validating predictive factors for treatment response, refining therapeutic regimens and investigating host-directed therapies to enhance patient outcomes.
Authors
- Marina Pinheiro (ORCID: https://orcid.org/0000-0002-6931-1355)
- Kevin L. Winthrop (ORCID: https://orcid.org/0000-0002-3892-6947)
- Raquel Duarte (ORCID: https://orcid.org/0000-0003-2257-3099)
- Kozo Morimoto (ORCID: https://orcid.org/0000-0002-8239-9275)
- Jakko van Ingen (ORCID: https://orcid.org/0000-0002-0581-2003)
- Michael R. Loebinger
- Rachel Mary Thomson (ORCID: https://orcid.org/0000-0003-0686-171X)
- Mateja Janković Makek (ORCID: https://orcid.org/0000-0002-0171-764X)
- Dirk Wagner (ORCID: https://orcid.org/0000-0002-3271-5815)
- Bianca C. Martins (ORCID: https://orcid.org/0000-0002-8991-9990)
- Onno W. Akkerman (ORCID: https://orcid.org/0000-0001-5638-9260)
- Timothy R. Aksamit (ORCID: https://orcid.org/0000-0002-5243-5394)
- Charles L. Daley (ORCID: https://orcid.org/0000-0003-3324-926X)
- Christoph Lange (ORCID: https://orcid.org/0000-0002-9691-4741)
- Ana Aguiar (ORCID: https://orcid.org/0000-0001-7643-8963)
- Marc Lipman (ORCID: https://orcid.org/0000-0001-7501-4448)
- Jae‐Joon Yim (ORCID: https://orcid.org/0000-0002-9605-0074)
- Stefano Aliberti (ORCID: https://orcid.org/0000-0002-0090-4531)
- Diana Moreira‐Sousa (ORCID: https://orcid.org/0000-0003-4514-6110)
- Claire Andréjak
Institutions
- Portland State University (US)
- University Medical Center Groningen (NL)
- Humanitas University (IT)
- University Hospital Centre Zagreb (HR)
- Radboud University Nijmegen (NL)
- University of Freiburg (DE)
- Oregon Health & Science University (US)
- Royal Free London NHS Foundation Trust (GB)
- University of Zagreb (HR)
- Universidade do Porto (PT)
- Universidade Politécnica do Cávado e do Ave (PT)
- Greenslopes Private Hospital (AU)
- The Royal Free Hospital (GB)
- University Medical Center Freiburg (DE)
- Hospital Center of Cova da Beira (PT)
- Seoul National University Hospital (KR)
- Radboud University Medical Center (NL)
- Hospital de São João (PT)
- National Jewish Health (US)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Royal Brompton Hospital (GB)
- Japan Anti Tuberculosis Association (JP)
- Radboud Institute for Molecular Life Sciences (NL)
- German Center for Infection Research (DE)
- Gallipoli Medical Research Foundation (AU)
- Helmholtz Centre for Infection Research (DE)
- Mayo Clinic in Arizona (US)
- Equilibrium Research (GB)
- Research Center Borstel - Leibniz Lung Center (DE)
- Instituto de Saúde (BR)
- Mayo Clinic in Florida (US)
- Texas Children's Hospital (US)
- Fukujuji Hospital (JP)
- Orano (France) (FR)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- IRCCS Humanitas Research Hospital (IT)
- Nagasaki University (JP)
- University College London (GB)
- Université de Picardie Jules Verne (FR)
- Imperial College London (GB)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
- University of Lübeck (DE)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1183/13993003.00400-2025
- Citations
- 2
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 2.71