Clinical, physiological, imaging and molecular responses to cannabis smoking: the Canadian Users of Cannabis Smoke (CANUCK) study
Cannabis smoking, particularly at high exposures, is associated with worse respiratory symptoms, lower lung function, functional imaging abnormalities and dysregulated immune responses in the airway epithelium. These observations suggest respiratory harm associated with cannabis smoking and underscore the concerns for future respiratory morbidities related to persistent cannabis use.
Authors
- Jonathon A Leipsic (ORCID: https://orcid.org/0000-0002-6133-8334)
- Jordan A. Guenette (ORCID: https://orcid.org/0000-0002-4387-4547)
- Carolyn Wang (ORCID: https://orcid.org/0000-0002-4345-119X)
- Jackie Liggins
- William W.Y. Hsu (ORCID: https://orcid.org/0000-0002-5168-070X)
- Mohsen Sadatsafavi (ORCID: https://orcid.org/0000-0002-0419-7862)
- Rachel L. Eddy (ORCID: https://orcid.org/0000-0002-2541-1645)
- Don D. Sin (ORCID: https://orcid.org/0000-0002-0756-6643)
- S.S. Dhillon (ORCID: https://orcid.org/0000-0001-8358-0378)
- Tawimas Shaipanich (ORCID: https://orcid.org/0000-0001-5551-0073)
- C Gilchrist
- Clarus Leung (ORCID: https://orcid.org/0000-0003-3515-7537)
- Miranda Kirby (ORCID: https://orcid.org/0000-0003-2951-784X)
- Grace Párraga (ORCID: https://orcid.org/0000-0002-5619-4145)
- Chris Carlsten (ORCID: https://orcid.org/0000-0003-2455-6575)
- Gurpreet K. Singhera (ORCID: https://orcid.org/0000-0002-8422-0857)
- Wan C. Tan (ORCID: https://orcid.org/0000-0001-9289-3595)
- Firoozeh V. Gerayeli (ORCID: https://orcid.org/0000-0003-3353-8408)
- Chung Yan Cheung (ORCID: https://orcid.org/0009-0005-5948-3881)
- Andrea S. Gershon (ORCID: https://orcid.org/0000-0002-0246-594X)
- Karolina Moo
- Lavraj S Lidher
- Xuan Li (ORCID: https://orcid.org/0009-0004-1337-3049)
- Jonathan H. Rayment (ORCID: https://orcid.org/0000-0003-4955-8876)
- Janice M. Leung (ORCID: https://orcid.org/0000-0003-1682-6483)
- Julia Yang
- Eleazar Leyson
Institutions
- Western University (CA)
- Brigham and Women's Hospital (US)
- Sunnybrook Health Science Centre (CA)
- Harvard University (US)
- University of British Columbia (CA)
- University of Toronto (CA)
- St. Paul's Hospital (CA)
- Health Sciences Centre (CA)
- Health First (US)
- Metropolitan University (RS)
- Public Health Ontario (CA)
- Centre for Advancing Health Outcomes (CA)
- St. Paul's Hospital (CA)
- Sunnybrook Research Institute
- Toronto Metropolitan University (CA)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1183/13993003.01659-2025
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39