Anatomical Group-Level Studies of the Volume of Tissue Activated by Deep Brain Stimulation in Parkinson’s Disease: A Model for Targeting?
This study comparing anatomical group-level studies of VTAs of optimal responders with poor responders for STN-DBS in PD did not find an area of optimal stimulation to reduce variability in DBS outcome. However, the heatmap of optimal responders can facilitate easier DBS targeting. To reduce variability in DBS outcome, focus could shift more toward patient-specific anatomy and connectivity levels in order to determine the individual optimal subthalamic area for programming.
Authors
- Pepijn van den Munckhof (ORCID: https://orcid.org/0000-0001-5044-3705)
- Martijn Beudel (ORCID: https://orcid.org/0000-0002-2488-7051)
- Rick Schuurman (ORCID: https://orcid.org/0000-0001-9444-4136)
- Maarten Bot (ORCID: https://orcid.org/0000-0001-9719-6086)
- Rob M. A. de Bie (ORCID: https://orcid.org/0000-0001-5267-0784)
- Yarit Wiggerts (ORCID: https://orcid.org/0000-0001-8641-3639)
Institutions
- Amsterdam UMC Location University of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Stereotactic and Functional Neurosurgery
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1159/000549455
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Boston Scientific Corporation
- Ministerie van Economische Zaken