Histopathological Response After Neoadjuvant Chemotherapy for High-Risk Soft-Tissue Sarcomas
In this secondary analysis of a randomized clinical trial, the proportion of stainable tumor cells, currently considered as the most relevant posttreatment change, did not stratify patient risk. The findings support consideration of the presence of sclerohyalinosis (>20%) to identify patients with the best outcome after NACT.
Authors
- Paolo Verderio (ORCID: https://orcid.org/0000-0002-9231-1281)
- Javier Martín‐Broto (ORCID: https://orcid.org/0000-0001-7350-6916)
- Vittorio Quagliuolo (ORCID: https://orcid.org/0000-0002-6102-0000)
- Angelo Paolo Dei Tos (ORCID: https://orcid.org/0000-0002-1228-8940)
- Paolo G. Casali (ORCID: https://orcid.org/0000-0003-4056-8023)
- Paola Collini (ORCID: https://orcid.org/0000-0002-6158-210X)
- Iwona Ługowska (ORCID: https://orcid.org/0000-0001-9511-178X)
- Rosalba Miceli (ORCID: https://orcid.org/0000-0003-0954-375X)
- Giuseppe Bianchi (ORCID: https://orcid.org/0000-0001-6390-9762)
- Cleofé Romagosa (ORCID: https://orcid.org/0000-0002-9478-7320)
- Jean‐Michel Coindre (ORCID: https://orcid.org/0000-0001-8039-6786)
- Giovanni Grignani (ORCID: https://orcid.org/0000-0001-5515-569X)
- Valeria Fontana (ORCID: https://orcid.org/0000-0002-2156-7108)
- Silvia Stacchiotti (ORCID: https://orcid.org/0000-0002-1742-8666)
- Marta Barisella (ORCID: https://orcid.org/0000-0001-9728-3120)
- Elena Palassini (ORCID: https://orcid.org/0000-0003-2257-4681)
- Alessandro Gronchi (ORCID: https://orcid.org/0000-0002-4703-3534)
- Salvatore Lorenzo Renne (ORCID: https://orcid.org/0000-0002-0186-1318)
- Valeria Duroni
- Marta Sbaraglia (ORCID: https://orcid.org/0000-0002-7116-6513)
- Sílvia Bagué (ORCID: https://orcid.org/0000-0001-9980-7231)
- Sara Pizzamiglio (ORCID: https://orcid.org/0000-0002-7759-0550)
- Marco Gambarotti (ORCID: https://orcid.org/0000-0002-8080-4484)
- Emanuela Palmerini (ORCID: https://orcid.org/0000-0003-3406-6705)
- Antonella Brunello (ORCID: https://orcid.org/0000-0003-2583-5226)
- Antonio López–Pousa (ORCID: https://orcid.org/0000-0003-1066-3951)
- Sandro Pasquali (ORCID: https://orcid.org/0000-0003-4815-6293)
- Jean-Yves Blay
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Universitat Autònoma de Barcelona (ES)
- University of Padua (IT)
- University of Miami (US)
- Inserm (FR)
- Hospital de Sant Pau (ES)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Centre Léon Bérard (FR)
- Istituto Oncologico Veneto (IT)
- Istituto Ortopedico Rizzoli (IT)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Institut Bergonié (FR)
- Centrum Onkologii (PL)
- Ospedale Policlinico San Martino (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- ASST Fatebenefratelli Sacco (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.40177
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00