Geographic Atrophy Multifocality in the Age-Related Eye Disease Study 2
In this post hoc analysis of the AREDS2 trial data, the natural history data and multivariable models may be helpful in clinical practice and trials. The models included a combination of GA characteristics and RPD status; the risk factors for first GA occurrence, subsequent lesion incidence rate, and area-based progression overlapped only partially. Their mechanisms may, therefore, be partially distinct, which has implications for therapeutic approaches.
Authors
- Jintong Hou (ORCID: https://orcid.org/0000-0002-4108-4277)
- Leon von der Emde (ORCID: https://orcid.org/0009-0009-2630-3732)
- Tiarnán D L Keenan (ORCID: https://orcid.org/0000-0002-2253-1772)
- Amitha Domalpally (ORCID: https://orcid.org/0000-0002-8145-9619)
- Souvick Mukherjee (ORCID: https://orcid.org/0000-0003-0748-8371)
- Elvira Agrón (ORCID: https://orcid.org/0000-0002-2829-4042)
- Emily Vance
Institutions
- University of Bonn (DE)
- University of Wisconsin–Madison (US)
- National Eye Institute (US)
Publication Details
- Journal
- JAMA Ophthalmology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1001/jamaophthalmol.2025.3979
- Citations
- 1
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 1.88