Systemic Toxicity With Use of Apraclonidine Ophthalmic Drops in Pediatric Patients

This case series suggests use of apraclonidine in pediatric patients poses a risk of central α-2 adrenergic agonist-induced central nervous system and respiratory depression. Clinicians who use apraclonidine in the pediatric population should be aware of potential serious systemic effects from ophthalmic use of the drug and be prepared to manage these.

Authors

Rachna Kapoor (ORCID: https://orcid.org/0000-0003-0538-5440)
Paula Gish
S. Christopher Jones (ORCID: https://orcid.org/0000-0002-0478-0978)
Ivone Kim (ORCID: https://orcid.org/0000-0002-2144-4861)

Institutions

United States Food and Drug Administration (US)
Center for Drug Evaluation and Research (US)

Publication Details

Journal: JAMA Ophthalmology
Published: 2025-11-06
DOI: https://doi.org/10.1001/jamaophthalmol.2025.4243
Citations: 2
Primary Topic: Anesthesia and Sedative Agents
Type: article
Field-Weighted Citation Impact: 4.38

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article

Systemic Toxicity With Use of Apraclonidine Ophthalmic Drops in Pediatric Patients

Rachna Kapoor, Paula Gish, S. Christopher Jones, Ivone Kim

Nov 6, 2025

2 citations

JAMA Ophthalmology

Anesthesia and Sedative Agents

4.38

article

Systemic Toxicity With Use of Apraclonidine Ophthalmic Drops in Pediatric Patients

Rachna Kapoor, Paula Gish, S. Christopher Jones, Ivone Kim

November 6, 2025article en

2 citations

Abstract

This case series suggests use of apraclonidine in pediatric patients poses a risk of central α-2 adrenergic agonist-induced central nervous system and respiratory depression. Clinicians who use apraclonidine in the pediatric population should be aware of potential serious systemic effects from ophthalmic use of the drug and be prepared to manage these.

JAMA OphthalmologyVol. 143(12)

United States Food and Drug Administration (US), Center for Drug Evaluation and Research (US)

Openalex Percentile: Top 5%

Anesthesia and Sedative Agents

4.38

DOI Open Access PDF OpenAlex

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Systemic Toxicity With Use of Apraclonidine Ophthalmic Drops in Pediatric Patients — Rachna Kapoor, Paula Gish, et al. · JAMA Ophthalmology (2025) | TGRS Research Map | TGRS