Suppression of 6-pyruvoyl-tetrahydropterin synthase promotes remyelination in multiple sclerosis

Our findings suggest that PTS is a negative regulator of OPC proliferation, and its disinhibition could offer a potential therapeutic target for MS.

Authors

Ying Long (ORCID: https://orcid.org/0009-0000-3634-6765)
Yanqing Yin
Ellen Ji (ORCID: https://orcid.org/0000-0003-1527-8868)
Hui Xiao (ORCID: https://orcid.org/0000-0001-6283-6514)
Gang Hu (ORCID: https://orcid.org/0000-0002-2864-4372)
Yue Wu (ORCID: https://orcid.org/0000-0003-1449-5684)
Yong-shun Guo (ORCID: https://orcid.org/0000-0002-0761-8538)
Jiawei Zhou (ORCID: https://orcid.org/0000-0002-1844-9178)
Yanyan Zhu (ORCID: https://orcid.org/0000-0001-6005-8421)
Jun Gao (ORCID: https://orcid.org/0000-0002-5925-537X)