Palladium-Catalyzed Cascade π-Extended Decarboxylative Annulation to Synthesize Indolo[1,2- <i>f</i> ]phenanthridines in Water
In this study, a new green method for the synthesis of indolo[1,2-<i>f</i>]phenanthridines by decarboxylative coupling cyclization of 1-(2-iodophenyl)-1<i>H</i>-indoles and <i>o</i>-bromobenzoic acids was developed by using TBAB as a phase transfer catalyst to promote substrate dissolution and reaction mass transfer in aqueous medium. It features diverse substrate compatibility, gram-scale synthesis, and aqueous medium recycling.
Authors
- Zhiwei Xu (ORCID: https://orcid.org/0000-0003-2279-0632)
- Bingxin Yuan (ORCID: https://orcid.org/0000-0003-4580-366X)
- Heng Li (ORCID: https://orcid.org/0000-0001-8145-233X)
- Yan Liu (ORCID: https://orcid.org/0000-0001-5788-3236)
- Zongwei Li
Institutions
- Zhengzhou University (CN)
- Institute of Catalysis and Petrochemistry (RU)
- Green Chemistry (PL)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1021/acs.joc.5c01708
- Citations
- 1
- Primary Topic
- Synthesis and bioactivity of alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.81