Variations in ventricular distribution of polymyxin B following intraventricular administration in patients with central nervous system infections
Polymyxin B (PMB) demonstrates activity against multidrug-resistant Gram-negative pathogens. Intraventricular administration is considered when systemic therapy yields suboptimal cerebrospinal fluid (CSF) levels. We describe two cases of carbapenem-resistant gram-negative meningoencephalitis successfully treated with intraventricular PMB, in which unilateral PMB administration appeared to achieve bilateral ventricular distribution, with higher concentrations on the administration side. A potential association was observed between reduced CSF drainage and increased PMB concentrations. These findings may offer preliminary insights into optimizing PMB dosing strategies for CNS infections.
Authors
- Lufeng Hu (ORCID: https://orcid.org/0000-0002-3494-2405)
- Jing Cai (ORCID: https://orcid.org/0000-0002-0302-9998)
- Yangmin Hu
- Jiali Zhang (ORCID: https://orcid.org/0000-0002-7416-0352)
- Xuben Yu (ORCID: https://orcid.org/0000-0003-1897-4519)
- Wei Yan (ORCID: https://orcid.org/0000-0002-1123-0835)
- Haibin Dai (ORCID: https://orcid.org/0000-0002-5768-2714)
- Meng Chen (ORCID: https://orcid.org/0000-0002-2812-2750)
- Kai Wei (ORCID: https://orcid.org/0000-0001-7068-6114)
- Huifang Jiang (ORCID: https://orcid.org/0009-0001-1772-0659)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1128/aac.00943-25
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59