Bone marrow evaluation in neuroblastomas: bone marrow aspirates have little additional value over trephine biopsies
TBs showed higher sensitivity and representativity than BMA cytomorphology. In 4.6% of procedures, BMAs were positive while TBs were negative, but this never led to treatment alteration. These findings suggest that bilateral TBs alone may be sufficient to detect bone marrow involvement.
Authors
- Alida F. W. van der Steeg (ORCID: https://orcid.org/0000-0003-0168-7513)
- Gerda den Engelsman
- Miranda P. Dierselhuis
- Andrea van Barneveld
- Marc H. W. A. Wijnen (ORCID: https://orcid.org/0000-0001-9339-4253)
- Rixt S. Bruinsma (ORCID: https://orcid.org/0000-0001-8557-4529)
- Ronald R. de Krijger (ORCID: https://orcid.org/0000-0001-6871-1296)
- M. Fiocco
- A. M. Heijlaerts-Klever
- Max Maria van Noesel (ORCID: https://orcid.org/0000-0001-7738-0353)
- Godelieve A.M. Tytgat (ORCID: https://orcid.org/0000-0003-2356-5197)
- B. W. Meussen
Institutions
- Leiden University (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Princess Máxima Center (NL)
- Cancer Genomics Centre (NL)
Publication Details
- Journal
- BJC Reports
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1038/s44276-025-00194-7
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00