Accelerated Biological Aging and Genetic Pleiotropy in Age-Related Eye Diseases: A Population-Based Cohort and Integrative Genetic Analysis
Accelerated biological aging significantly increases ARED risk, especially in those with high genetic risk, and is linked to shorter vision-healthy life expectancy. Identifying individuals with accelerated aging may help reduce ARED risk and improve vision-healthy life expectancy. APOE, APOC1, TOMM40, PVRL2, and BCAM could be potential targets for ocular anti-aging interventions.
Authors
- Yuelan Gao
- Ka Wai Kam (ORCID: https://orcid.org/0000-0002-7760-6882)
- Clement Chee Yung Tham (ORCID: https://orcid.org/0000-0003-4407-6907)
- Jason C. S. Yam (ORCID: https://orcid.org/0000-0002-2156-1486)
- Alvin Lerrmann Young (ORCID: https://orcid.org/0000-0002-4365-3218)
- Jianming Xu (ORCID: https://orcid.org/0000-0002-8231-7858)
- Chi Pui Pang (ORCID: https://orcid.org/0000-0002-7764-6382)
- Mary Ho
- Jun Sang Yu (ORCID: https://orcid.org/0000-0002-5720-5934)
- Yuyao Wang (ORCID: https://orcid.org/0000-0003-1315-9099)
- Yuzhou Zhang (ORCID: https://orcid.org/0000-0001-8515-3388)
- Li Jia Chen
Institutions
- Chinese University of Hong Kong (HK)
- Hong Kong Eye Hospital (CN)
- Prince of Wales Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1167/iovs.66.14.14
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hong Kong Government
- Health and Medical Research Fund