Adenosine-mediated Neutrophil Regulation by Dapagliflozin Attenuates Renal Ischemia/Reperfusion Injury: Real-time Imaging and Metabolic Insights
Dapagliflozin protects against renal IRI through the adenosine-mediated inhibition of neutrophil infiltration and inflammatory activation. This novel mechanism, involving metabolic reprogramming and enhanced adenosine signaling, extends our understanding of the pleiotropic effects of sodium-glucose cotransporter 2 inhibitors beyond glycemic control and suggests potential therapeutic applications for preventing acute kidney injury in high-risk clinical settings, including kidney transplantation.
Authors
- Kengo Kidokoro (ORCID: https://orcid.org/0000-0002-4932-0166)
- Takanori Sekito (ORCID: https://orcid.org/0000-0002-9172-7429)
- Naoki Kashihara (ORCID: https://orcid.org/0000-0002-9487-984X)
- Shotaro Nishimura (ORCID: https://orcid.org/0000-0001-9347-6451)
- Tatsushi Kawada (ORCID: https://orcid.org/0000-0002-8369-9712)
- Satoshi Katayama (ORCID: https://orcid.org/0000-0002-8377-2457)
- Yuki Maruyama (ORCID: https://orcid.org/0000-0002-9918-6815)
- Takuya Sadahira
- Kasumi Yoshinaga (ORCID: https://orcid.org/0000-0002-4251-120X)
- Yosuke Mitsui (ORCID: https://orcid.org/0000-0002-8598-0823)
- Tomoaki Yamanoi (ORCID: https://orcid.org/0009-0006-9821-9407)
- Motoo Araki (ORCID: https://orcid.org/0000-0002-3172-2482)
- Yusuke Tominaga
- Kensuke Bekku (ORCID: https://orcid.org/0000-0003-0002-1592)
- Toyohiko Watanabe (ORCID: https://orcid.org/0000-0002-1138-5642)
- Takehiro Iwata
Institutions
- Okayama University (JP)
- Kawasaki Medical School (JP)
- Cleveland Clinic Lerner College of Medicine (US)
Publication Details
- Journal
- Transplantation
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1097/tp.0000000000005557
- Citations
- 1
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43