USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Coevolution in Pancreatic Cancer
Targeting USP20 disrupts coevolution of pancreatic ductal adenocarcinoma and the tumor microenvironment and enhances immune checkpoint inhibitor efficacy by blocking mevalonate metabolism rewiring, providing a dual-action therapeutic approach for pancreatic cancer.
Authors
- Yong Ma (ORCID: https://orcid.org/0000-0001-5323-9320)
- Chengliang Zhou (ORCID: https://orcid.org/0009-0008-1097-1886)
- Wengui Shi (ORCID: https://orcid.org/0000-0003-1039-3576)
- Xiaoe He (ORCID: https://orcid.org/0009-0005-4279-2565)
- Zhenzhen Ye (ORCID: https://orcid.org/0009-0000-2628-9517)
- Long Qin (ORCID: https://orcid.org/0000-0001-9995-7176)
- Yuman Dong (ORCID: https://orcid.org/0000-0003-2342-5338)
- Huinian Zhou (ORCID: https://orcid.org/0000-0003-0727-463X)
- Xiangyan Jiang (ORCID: https://orcid.org/0000-0002-2685-2899)
- Zuoyi Jiao (ORCID: https://orcid.org/0000-0003-1942-0905)
- Qichen He (ORCID: https://orcid.org/0009-0006-3187-7130)
- W. K. Liu (ORCID: https://orcid.org/0009-0003-8458-1948)
- Keshen Wang (ORCID: https://orcid.org/0000-0001-5526-2129)
- Tao Wang (ORCID: https://orcid.org/0000-0003-1225-0173)
- Bo Long (ORCID: https://orcid.org/0000-0002-5632-5125)
- Zeyuan Yu (ORCID: https://orcid.org/0000-0002-0636-4783)
- Bin Zhao (ORCID: https://orcid.org/0009-0006-0813-2763)
- Xiaoying Guan (ORCID: https://orcid.org/0000-0002-6544-8143)
- Huiguo Qing (ORCID: https://orcid.org/0009-0000-7044-1563)
- Z. Li (ORCID: https://orcid.org/0009-0001-0254-8155)
- Haonan Sun (ORCID: https://orcid.org/0009-0005-5174-3503)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Gansu University of Traditional Chinese Medicine (CN)
- Radboud Institute for Molecular Life Sciences (NL)
- Gansu Provincial Hospital (CN)
- Gansu Provincial Cancer Hospital Gansu Provincial Academic Instiute for Medical Research (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1228
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00