USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Coevolution in Pancreatic Cancer

Targeting USP20 disrupts coevolution of pancreatic ductal adenocarcinoma and the tumor microenvironment and enhances immune checkpoint inhibitor efficacy by blocking mevalonate metabolism rewiring, providing a dual-action therapeutic approach for pancreatic cancer.

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Publication Details

Journal
Cancer Research
Published
2025-11-06
DOI
https://doi.org/10.1158/0008-5472.can-25-1228
Primary Topic
Cancer, Lipids, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Coevolution in Pancreatic Cancer

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Cancer Research
Cancer, Lipids, and Metabolism
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USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Coevolution in Pancreatic Cancer

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article en

Abstract

Targeting USP20 disrupts coevolution of pancreatic ductal adenocarcinoma and the tumor microenvironment and enhances immune checkpoint inhibitor efficacy by blocking mevalonate metabolism rewiring, providing a dual-action therapeutic approach for pancreatic cancer.

Cancer ResearchVol. 86(3)
Radboud University Nijmegen (NL), Radboud University Medical Center (NL), Gansu University of Traditional Chinese Medicine (CN), Radboud Institute for Molecular Life Sciences (NL), Gansu Provincial Hospital (CN), Gansu Provincial Cancer Hospital Gansu Provincial Academic Instiute for Medical Research (CN), Lanzhou University Second Hospital (CN), Lanzhou University (CN)
Openalex Percentile: Top 59%
Cancer, Lipids, and Metabolism
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