Tumor-Associated Macrophages Produce PGE2 to Promote CD8+ T-cell Exhaustion and Drive Resistance to PD-L1 Blockade in Microsatellite-Stable Colorectal Cancer
Targeting PGE2 signaling activated by tumor-associated macrophages sensitizes microsatellite-stable colon tumors to immune checkpoint blockade by limiting the emergence of an exhausted PD-1+ TIGIT+ CD8+ T population.
Authors
- Caroline Truntzer (ORCID: https://orcid.org/0000-0003-0895-4813)
- Jean-David Fumet (ORCID: https://orcid.org/0000-0002-9444-941X)
- Emeric Limagne (ORCID: https://orcid.org/0000-0002-1098-8441)
- Charlène Latour (ORCID: https://orcid.org/0009-0004-5925-7748)
- François Ghiringhelli (ORCID: https://orcid.org/0000-0002-5465-8305)
- Valentin Dérangère (ORCID: https://orcid.org/0000-0002-6311-5628)
- Léa Hampe (ORCID: https://orcid.org/0009-0005-5996-6306)
- Lisa Nuttin (ORCID: https://orcid.org/0009-0002-2634-4787)
- Marion Thibaudin (ORCID: https://orcid.org/0000-0002-1046-5982)
- Pier Paolo Di Russo (ORCID: https://orcid.org/0009-0002-0656-5662)
- Susy Daumoine (ORCID: https://orcid.org/0009-0003-9585-653X)
- Alis Ilie (ORCID: https://orcid.org/0009-0009-5788-1586)
Institutions
- Inserm (FR)
- Centre Georges François Leclerc (FR)
- Genomic and Immunotherapy Medical Institute (FR)
- Université Bourgogne Europe (FR)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0079
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05