Bidirectional genetic overlap between mood swings and irritable bowel syndrome

The present study suggests the existence of polygenic overlap between mood swings and IBS and provides novel insights into the genetic underpinnings and mechanisms of comorbidities occurring in these two conditions.

Authors

Leichang Zhang (ORCID: https://orcid.org/0000-0002-8541-7379)
Qinghua Luo (ORCID: https://orcid.org/0000-0003-4488-2394)
Chen Wang (ORCID: https://orcid.org/0000-0003-3995-4242)
Jiawen Wang (ORCID: https://orcid.org/0000-0003-2317-1390)
Mingwei An (ORCID: https://orcid.org/0000-0002-6200-3616)

Institutions

Jiangxi University of Traditional Chinese Medicine (CN)
Macau University of Science and Technology (MO)
First Affiliated Hospital of Jiangxi Medical College (CN)
Shanghai University of Traditional Chinese Medicine (CN)
Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)

Publication Details

Journal: Psychiatric Genetics
Published: 2025-11-03
DOI: https://doi.org/10.1097/ypg.0000000000000405
Primary Topic: Gastrointestinal motility and disorders
Type: article
Field-Weighted Citation Impact: 0.00

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article

Bidirectional genetic overlap between mood swings and irritable bowel syndrome

Leichang Zhang, Qinghua Luo, Chen Wang, Jiawen Wang et al.

Nov 3, 2025

Psychiatric Genetics

Gastrointestinal motility and disorders

article

Bidirectional genetic overlap between mood swings and irritable bowel syndrome

Leichang Zhang, Qinghua Luo, Chen Wang, Jiawen Wang, Mingwei An

November 3, 2025article en

Abstract

The present study suggests the existence of polygenic overlap between mood swings and IBS and provides novel insights into the genetic underpinnings and mechanisms of comorbidities occurring in these two conditions.

Psychiatric GeneticsVol. 35(6)

Jiangxi University of Traditional Chinese Medicine (CN), Macau University of Science and Technology (MO), First Affiliated Hospital of Jiangxi Medical College (CN), Shanghai University of Traditional Chinese Medicine (CN), Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)

Openalex Percentile: Top 54%

Gastrointestinal motility and disorders

DOI Source OpenAlex

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Bidirectional genetic overlap between mood swings and irritable bowel syndrome — Leichang Zhang, Qinghua Luo, et al. · Psychiatric Genetics (2025) | TGRS Research Map | TGRS