Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration
Our results show that HAS3 plays a key role in AAA/AD formation and suggest the HAS3/CD44 axis as promising therapeutic target to reduce monocyte recruitment and aortic rupture.
Authors
- Margitta Elvers
- Norbert Gerdes (ORCID: https://orcid.org/0000-0002-4546-7208)
- Luca Rolauer
- Laura‐Marie A. Zimmermann (ORCID: https://orcid.org/0000-0003-2126-9191)
- Christine Quast (ORCID: https://orcid.org/0000-0002-0405-989X)
- Gerhard Sengle (ORCID: https://orcid.org/0000-0003-3932-1242)
- Christian Hundhausen (ORCID: https://orcid.org/0000-0002-6905-6753)
- Patrick Petzsch (ORCID: https://orcid.org/0000-0002-8355-5524)
- Ulrich Flögel (ORCID: https://orcid.org/0000-0001-7181-4392)
- Daniela Wenzel
- Bernd K. Fleischmann (ORCID: https://orcid.org/0000-0002-9202-8363)
- Janet Kaczur
- Maria Grandoch (ORCID: https://orcid.org/0000-0002-4382-1947)
- Alexander Brückner
- Kim Jürgen Krott (ORCID: https://orcid.org/0009-0009-0391-2068)
- Karl Köhrer (ORCID: https://orcid.org/0000-0003-3644-2022)
- Tatsiana Suvorava
- Timm J. Filler (ORCID: https://orcid.org/0000-0002-2922-5110)
- Fedor Brack
- Pascal Bouvain (ORCID: https://orcid.org/0000-0002-9116-1330)
- Tobias Feige
- Katharina Voigt (ORCID: https://orcid.org/0000-0002-2547-8292)
- Wiebke Ibing
- Martina Krüger (ORCID: https://orcid.org/0000-0003-2446-5526)
- Jens W. Fischer
- Markus U. Wagenhäuser (ORCID: https://orcid.org/0000-0002-2936-0689)
- Sakine Simsekyilmaz
- Viola Niemann
- Philipp Barnowski (ORCID: https://orcid.org/0009-0008-2843-7577)
Institutions
- University of Cologne (DE)
- Düsseldorf University Hospital (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
- Life & Brain (Germany) (DE)
- Heinrich Heine University Düsseldorf (DE)
- Hochschule Düsseldorf University of Applied Sciences (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1680246
- Citations
- 1
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Deutsche Forschungsgemeinschaft
- Heinrich-Heine-Universität Düsseldorf
- Universität zu Köln
- Rheinische Friedrich-Wilhelms-Universität Bonn