Brief Report: Breast Milk Transfer and Infant Exposures to Dolutegravir, Tenofovir, and Tenofovir Alafenamide: Results From IMPAACT 2010/VESTED
Breast milk transfer of DTG, TAF, and TFV is low and results in minimal systemic exposure in breastfed infants. The clinical relevance of infant exposure to low concentrations of these antiretrovirals-particularly DTG-is unknown but should be considered in the context of the risk of drug resistance in infants who acquire HIV.
Authors
- Patrick Jean‐Philippe
- Jung‐woo Chae (ORCID: https://orcid.org/0000-0001-6026-7063)
- Deo Wabwire
- Avy Violari (ORCID: https://orcid.org/0000-0002-9437-776X)
- Roger Shapiro (ORCID: https://orcid.org/0000-0002-4832-6275)
- Patricia Mandima (ORCID: https://orcid.org/0000-0001-6829-3506)
- Tsungai Mhembere
- Lauren Ziemba
- Shahin Lockman (ORCID: https://orcid.org/0000-0002-5384-9716)
- Lameck Chinula (ORCID: https://orcid.org/0000-0003-3690-4207)
- Sherika Hanley (ORCID: https://orcid.org/0000-0002-4343-7646)
- Benjamin Johnston
- Anne Coletti (ORCID: https://orcid.org/0000-0003-1787-9966)
- Violet Korutaro (ORCID: https://orcid.org/0000-0003-1741-4771)
- Ponego Ponatshego (ORCID: https://orcid.org/0009-0006-7549-8300)
- Jeremiah D. Momper (ORCID: https://orcid.org/0000-0002-3154-6685)
- Kevin Knowles
- Gaerolwe Masheto (ORCID: https://orcid.org/0000-0002-2388-9637)
- Tariro Dianah Chawana
- Gerhard Barnard Theron (ORCID: https://orcid.org/0000-0001-8888-1436)
- Sikhulile M. Moyo (ORCID: https://orcid.org/0000-0003-3821-4592)
- Blandina Theophil Mmbaga (ORCID: https://orcid.org/0000-0002-5550-1916)
- Tk Nguyen
- Shilpa Naik (ORCID: https://orcid.org/0000-0002-9296-0353)
- Siphokazi Sibisi
Institutions
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- National Institutes of Health (US)
- Western Cape Department of Health (ZA)
- Massachusetts Department of Public Health (US)
- Harvard University (US)
- University of Zimbabwe (ZW)
- South African Reserve Bank (ZA)
- GTx (United States) (US)
- University of the Witwatersrand (ZA)
- B. J. Medical College & Sassoon Hospital (IN)
- Stellenbosch University (ZA)
- University of California San Diego (US)
- Baylor College of Medicine Children’s Foundation (UG)
- Kilimanjaro Christian Medical Centre (TZ)
- Frontier Science & Technology Research Foundation, Inc. (US)
- National HIV/AIDS/STI/TB Council (ZM)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Botswana Harvard AIDS Institute Partnership (BW)
- University of Montana (US)
- Makerere University (UG)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1097/qai.0000000000003796
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Brigham and Women's Hospital
- Purdue University
- School of Medicine, Boston University
- Seattle Children's Research Institute
- Children’s Hospital of Wisconsin Research Institute
- International Maternal Pediatric Adolescent AIDS Clinical Trials Network
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development