Predictors of Variability in Coronary Flow Reserve and Microvascular Resistance Measurement Using the Bolus Thermodilution Technique
Minimizing variability in invasive CMD assessment is essential for improving diagnostic accuracy and guiding clinical decision-making as testing becomes more widespread. In this study, target vessel choice (RCA) and pressure sensor placement were identified as key modifiable sources of transit time variability. Clinically applicable confidence intervals around CFR and IMR values were defined.
Authors
- Joia Spinelli
- Evan Shlofmitz (ORCID: https://orcid.org/0000-0002-0907-5258)
- Jason Galo (ORCID: https://orcid.org/0000-0001-9036-7049)
- Jorn op den Buijs (ORCID: https://orcid.org/0000-0002-8101-285X)
- Yuhei Kobayashi (ORCID: https://orcid.org/0000-0001-6058-232X)
- Brian A. Bergmark (ORCID: https://orcid.org/0000-0003-4360-7606)
- Richard Rapoza
- Hayder Hashim (ORCID: https://orcid.org/0000-0003-2194-5428)
- Akl C. Fahed (ORCID: https://orcid.org/0000-0002-4849-6389)
- Samit Shah (ORCID: https://orcid.org/0000-0002-3664-4102)
- Alok Sharma (ORCID: https://orcid.org/0000-0002-7248-3254)
- Olga Toleva
- Aziz Maksoud (ORCID: https://orcid.org/0000-0002-3678-1860)
Institutions
- Brigham and Women's Hospital (US)
- MedStar Washington Hospital Center (US)
- NewYork–Presbyterian Brooklyn Methodist Hospital (US)
- Harvard University (US)
- The University of Kansas Health System (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- Abbott (United States) (US)
- St. Francis Hospital (US)
- Minneapolis VA Health Care System (US)
- Northeast Georgia Medical Center (US)
- Thrombolysis in Myocardial Infarction Study Group (US)
- Abbott Vascular (United States)
Publication Details
- Journal
- Catheterization and Cardiovascular Interventions
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1002/ccd.70301
- Citations
- 1
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.01