Complex Study of the Internal Structure of Polymeric Sponge Matrixes during Tissue-Engineered Arrangement
The possibilities of a complex study of the 3D structure of a polymeric spongy matrix based on polylactide, using X-ray microtomography without staining in combination with noninvasive method scanning impulse acoustic microscopy and energy-dispersive X-ray microanalysis, are presented. Comparative studies of pure matrix samples, in vitro samples kept in a culture medium and after their implantation in vivo were carried out. The use of a complex of noninvasive methods revealed changes in the microstructure, including matrix degradation processes in a culture medium, after incubation with cells and implantation in a laboratory animal.
Authors
- E.A. Khramtsova (ORCID: https://orcid.org/0000-0003-1104-8109)
- Н. А. Шарикова (ORCID: https://orcid.org/0000-0002-6207-1600)
- T. Е. Grigoriev (ORCID: https://orcid.org/0000-0001-8197-0188)
- В. Е. Асадчиков (ORCID: https://orcid.org/0000-0003-3602-7582)
- Д. А. Кириллова (ORCID: https://orcid.org/0009-0005-3602-0972)
- Yu. S. Krivonosov
- K. G. Antipova
- Т. Д. Пацаев (ORCID: https://orcid.org/0000-0001-8736-8032)
- А. М. Азиева (ORCID: https://orcid.org/0000-0003-2222-6302)
- A. L. Vasiliev (ORCID: https://orcid.org/0000-0001-7884-4180)
- Yu. S. Petronyuk (ORCID: https://orcid.org/0000-0002-9187-5288)
- Marina Yu. Kopaeva (ORCID: https://orcid.org/0000-0002-6100-2830)
Institutions
- Moscow Institute of Physics and Technology (RU)
- Kurchatov Institute (RU)
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
- Institute of Biochemical Physics NM Emanuel (RU)
Publication Details
- Journal
- Crystallography Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1134/s1063774525600541
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00