Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancer
Dual targeting of CHK1 and PD-L1 may improve OC treatment by simultaneously suppressing stemness and enhancing anti-tumor immunity.
Authors
- Jing Cai (ORCID: https://orcid.org/0000-0003-3609-4291)
- Wenhan Li (ORCID: https://orcid.org/0000-0002-9412-1166)
- Yiping Wen
- Feiquan Ying (ORCID: https://orcid.org/0000-0003-2697-3604)
- Mengqing Chen (ORCID: https://orcid.org/0000-0001-5576-2297)
- Si Sun (ORCID: https://orcid.org/0000-0002-8424-5763)
- Lin Huang (ORCID: https://orcid.org/0000-0001-8254-7664)
- Lin Liu (ORCID: https://orcid.org/0009-0007-8329-5930)
- Mengna Zhu
Institutions
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1007/s00262-025-04215-9
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China