Tumor microenvironment-derived IL-32 promotes aggressive phenotypes and stem cell traits in head and neck squamous cell carcinoma
CAFs promote HNSCC progression through IL-32-mediated enhancement of invasion, EMT induction, and CSC properties. Targeting IL-32 signalling may represent a promising therapeutic approach to improve outcomes in HNSCC.
Authors
- Nien-Tzu Liu
- Su-Feng Chen
- Yi‐Ming Chang (ORCID: https://orcid.org/0000-0002-0622-1707)
- Yaoh-Shiang Lin
- Jian-Hong Yu
- S D Yang
- Yu‐Chun Lin (ORCID: https://orcid.org/0000-0002-1679-7064)
Institutions
- China Medical University (TW)
- China Medical University Hospital (TW)
- Kaohsiung Veterans General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.jds.2025.10.010
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00