PurFect timing: revisiting purine metabolism for tuberculosis treatment
Eradication of tuberculosis requires new drugs targeting novel pathways. Although purine metabolism represents an essential antitubercular target, concerns about host nucleobase rescue limited its exploration. New data demonstrate that nucleobase levels in human lung tissue are insufficient to confer rescue, renewing interest in this pathway for tuberculosis drug discovery.
Authors
- Richard J. Wall (ORCID: https://orcid.org/0000-0003-3487-3187)
- Valerie Mizrahi (ORCID: https://orcid.org/0000-0003-4824-9115)
- Dirk A. Lamprecht (ORCID: https://orcid.org/0000-0003-1066-9026)
Institutions
- University of Cape Town (ZA)
- London School of Hygiene & Tropical Medicine (GB)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
Publication Details
- Journal
- Trends in Microbiology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.tim.2025.10.010
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00