Effects of aprocitentan on prognostically relevant ambulatory blood pressure-derived variables in resistant hypertension
In addition to a significant and sustained day and night-time ambulatory BP reduction, aprocitentan was associated with a higher proportion of patients experiencing dipping pattern normalization and more pronounced BP load reduction, indicating prognostic relevance. Increased arterial stiffness or salt sensitivity did not alter the BP response to aprocitentan, suggesting additional clinical benefit.
Authors
- John M. Flack (ORCID: https://orcid.org/0000-0003-2584-5598)
- Markus Peter Schlaich (ORCID: https://orcid.org/0000-0002-1765-0195)
- Mouna Sassi-Sayadi
- Parisa Danaietash
- Krzysztof Narkiewicz (ORCID: https://orcid.org/0000-0001-5949-5018)
- Ji-Guang Wang
- Michael A. Weber
Institutions
- Center for Global Development (US)
- State University of New York (US)
- SUNY Downstate Health Sciences University (US)
- Southern Illinois University School of Medicine (US)
- Royal Perth Hospital (AU)
- Shanghai Institute of Hypertension (CN)
- Hypertension Institute (US)
- Idorsia (Switzerland) (CH)
- Gdańsk Medical University (PL)
- Zimmer Biomet (Switzerland) (CH)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1097/hjh.0000000000004174
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00