Response-adapted surgery after neoadjuvant immunochemotherapy in oral squamous cell carcinoma

RAS after NICT achieves oncologic outcomes equivalent to TS while significantly reducing treatment-related morbidity and improving functional recovery. These findings support RAS as a viable de-escalation strategy for OSCC, aligning with the goals of precision oncology. Prospective trials are needed to validate long-term efficacy and refine patient selection criteria.

Authors

Lanwei Guo (ORCID: https://orcid.org/0000-0002-0822-2578)
Junhui Yuan (ORCID: https://orcid.org/0000-0003-3312-8599)
Qigen Fang (ORCID: https://orcid.org/0000-0002-7303-1030)
Xu Zhang (ORCID: https://orcid.org/0000-0002-1959-1758)
Tao Huang (ORCID: https://orcid.org/0000-0003-2607-8407)

Institutions

Henan Cancer Hospital (CN)

Publication Details

Journal: Oral Oncology
Published: 2025-11-03
DOI: https://doi.org/10.1016/j.oraloncology.2025.107769
Citations: 5
Primary Topic: Head and Neck Cancer Studies
Type: article
Field-Weighted Citation Impact: 9.24

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article

Response-adapted surgery after neoadjuvant immunochemotherapy in oral squamous cell carcinoma

Lanwei Guo, Junhui Yuan, Qigen Fang, Xu Zhang et al.

Nov 3, 2025

5 citations

Oral Oncology

Head and Neck Cancer Studies

9.24

article

Response-adapted surgery after neoadjuvant immunochemotherapy in oral squamous cell carcinoma

Lanwei Guo, Junhui Yuan, Qigen Fang, Xu Zhang, Tao Huang

November 3, 2025article en

5 citations

Abstract

RAS after NICT achieves oncologic outcomes equivalent to TS while significantly reducing treatment-related morbidity and improving functional recovery. These findings support RAS as a viable de-escalation strategy for OSCC, aligning with the goals of precision oncology. Prospective trials are needed to validate long-term efficacy and refine patient selection criteria.

Oral OncologyVol. 171

Henan Cancer Hospital (CN)

Openalex Percentile: Top 2%

Head and Neck Cancer Studies

9.24

DOI Open Access PDF OpenAlex

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