Monotropein improves late-onset hypogonadism in TM3 Leydig cells and aged rats
MON was identified as the principal active compound of FME responsible for its LOH-alleviating effects. MON enhanced testicular steroidogenesis and improved reproductive and metabolic outcomes without causing systemic toxicity, supporting its potential as a targeted phytotherapeutic agent against age-related androgen deficiency.
Authors
- Keum Seok Bae (ORCID: https://orcid.org/0000-0003-4728-3047)
- Se‐Young Choung (ORCID: https://orcid.org/0000-0001-7619-6263)
- Hyesung Lee (ORCID: https://orcid.org/0009-0008-0720-9743)
- Do Sik Min (ORCID: https://orcid.org/0000-0002-8570-5098)
- Eun-Min Kim (ORCID: https://orcid.org/0009-0003-8739-5526)
- Hee‐Yeon Kwon
- Tae Hyun Kim (ORCID: https://orcid.org/0000-0002-0154-518X)
- Eunyoung Park (ORCID: https://orcid.org/0000-0001-5618-1267)
- Ji‐Soo Choi (ORCID: https://orcid.org/0009-0008-5535-4144)
- Seong Hun Lim
- Jae-Yeon Lee (ORCID: https://orcid.org/0000-0002-2073-850X)
Institutions
- Incheon National University (KR)
- Pohang Iron and Steel (South Korea) (KR)
- Inha University (KR)
- Yonsei University (KR)
- Dankook University (KR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.biopha.2025.118734
- Citations
- 1
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 1.29