ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia
We conclude that ERV3-MLT1functions as a trophoblast-specific CRE for several human genes and may be dysregulated in preeclampsia. As EPS8L1 has a form in maternal circulation, it may have utility in diagnostics.
Authors
- Zhiqiang Huang (ORCID: https://orcid.org/0000-0001-7809-3241)
- Yiran Xie (ORCID: https://orcid.org/0000-0001-5858-9637)
- Sandra M. Blois (ORCID: https://orcid.org/0000-0002-0434-2660)
- Martin Gauster (ORCID: https://orcid.org/0000-0003-0386-6857)
- Tamás Raskó
- Manvendra K. Singh (ORCID: https://orcid.org/0000-0002-2884-0074)
- Laurence D. Hurst (ORCID: https://orcid.org/0000-0002-1002-1054)
- Matthias Selbach (ORCID: https://orcid.org/0000-0003-2454-8751)
- Zsuzsanna Izsvák (ORCID: https://orcid.org/0000-0002-2053-2384)
- Ulrich Pecks (ORCID: https://orcid.org/0000-0002-0784-1262)
- Florian Herse (ORCID: https://orcid.org/0000-0002-9305-8134)
- Olivia Nonn (ORCID: https://orcid.org/0000-0001-6385-2866)
- Alexandra Gellhaus (ORCID: https://orcid.org/0000-0001-9506-4581)
- Ralf Dechend (ORCID: https://orcid.org/0000-0001-6636-3080)
- Ruswana Anwar (ORCID: https://orcid.org/0000-0001-5416-1238)
- Amit Pande (ORCID: https://orcid.org/0000-0001-5379-4746)
- Anne Cathrine Staff
- Stefan Verlohren
- Eve Hallett
Institutions
- Oslo University Hospital (NO)
- University Health Network (CA)
- Inserm (FR)
- Universität Hamburg (DE)
- University of Oslo (NO)
- Medical University of Graz (AT)
- Université Paris Cité (FR)
- Max Delbrück Center (DE)
- University of Würzburg (DE)
- Institut Necker Enfants Malades (FR)
- Augenklinik Universitätsklinikum Würzburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Essen University Hospital (DE)
- Universitätsklinikum Würzburg (DE)
- Helios Hospital Berlin-Buch (DE)
- Institut des Maladies Génétiques Imagine (FR)
- University of Bath (GB)
Publication Details
- Journal
- Genome biology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s13059-025-03821-1
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Deutsche Forschungsgemeinschaft
- China Scholarship Council
- National University of Sciences and Technology