Association of Platelet Aggregation With Markers of Alzheimer Disease Pathology in Middle-Aged Participants of the Framingham Heart Study
Our findings indicate that platelet aggregation is linked to PET and MRI markers of AD pathology as early as midlife. These findings support further investigation of platelet-mediated mechanisms in AD pathogenesis.
Authors
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Matthew R. Scott (ORCID: https://orcid.org/0000-0003-1404-4437)
- Ricardo S. Osorio (ORCID: https://orcid.org/0000-0002-2735-9609)
- Jaime Ramos‐Cejudo (ORCID: https://orcid.org/0000-0002-0993-9909)
- Jeremy A. Tanner (ORCID: https://orcid.org/0000-0001-9828-1776)
- Antonio Convit (ORCID: https://orcid.org/0000-0003-2201-2689)
- Sophia Francesca DP Lu (ORCID: https://orcid.org/0000-0002-2002-9818)
- Andrew D. Johnson (ORCID: https://orcid.org/0000-0001-6369-5178)
- Thomas Wısnıewskı (ORCID: https://orcid.org/0000-0002-3379-8966)
- Alexa S. Beiser (ORCID: https://orcid.org/0000-0001-8551-7778)
- Els Fieremans (ORCID: https://orcid.org/0000-0002-1384-8591)
- Charles DeCarli (ORCID: https://orcid.org/0000-0003-1914-2693)
- Joel Salinas (ORCID: https://orcid.org/0000-0002-3735-0018)
- Omonigho M. Bubu (ORCID: https://orcid.org/0000-0001-7438-2628)
- Saptaparni Ghosh (ORCID: https://orcid.org/0009-0009-6280-1624)
- Keith A. Johnson (ORCID: https://orcid.org/0000-0002-5916-6043)
- Nunzio Pomara (ORCID: https://orcid.org/0000-0002-8075-4253)
- Jeffrey S. Berger (ORCID: https://orcid.org/0000-0002-5525-2171)
- Tianshe He (ORCID: https://orcid.org/0000-0001-9752-1256)
Institutions
- Boston University (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Harvard University (US)
- The University of Texas at San Antonio Health Science Center (US)
- VA Boston Healthcare System (US)
- National Heart, Lung, and Blood Institute (US)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- Naval Research Laboratory Information Technology Division
- New York University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1212/wnl.0000000000214314
- Citations
- 1
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- U.S. Department of Health and Human Services
- U.S. Department of Veterans Affairs
- Australian Government
- National Institutes of Health