Multi-omics-based decoding of circulating biomarkers in amyotrophic lateral sclerosis and risks in environmental toxins
This study not only highlights the value of FCRL3, HTATIP2, RNASE6, and SF3B4 as potential diagnostic biomarkers and therapeutic targets for ALS but also provides new evidence for the involvement of environmental toxins, particularly benzo(a)pyrene, in the pathogenesis of ALS through gene-environment interactions.
Authors
- Lei Xu (ORCID: https://orcid.org/0000-0003-1297-1210)
- Ting Chen (ORCID: https://orcid.org/0000-0002-3436-9506)
- Hongping He (ORCID: https://orcid.org/0000-0002-7057-7687)
- Yixin Zhou (ORCID: https://orcid.org/0000-0001-7303-2255)
- Bin Huang (ORCID: https://orcid.org/0000-0002-5486-7924)
- Xiaolin Liao
Institutions
- Huaihua University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Yunnan University (CN)
- Hua Medicine (China) (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s40360-025-01024-9
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hunan University