Exploring the molecular mechanism of EGCG in preventing obesity-induced precocious puberty based on serum metabolomics and molecular docking
EGCG prevents obesity-induced precocious puberty, an effect associated with the reshaping of lipid metabolism, with key enzymes in the glycerophospholipid metabolism serving as potential therapeutic targets. These findings provide a foundational hypothesis for further mechanistic investigation.
Authors
- Lina Xia
- Lingwei Liang
- Chun‐Lei Jiang (ORCID: https://orcid.org/0000-0002-2783-6997)
- Jieyi He
- Pei‐Ying Wu (ORCID: https://orcid.org/0000-0002-8168-6125)
- Bing Shao (ORCID: https://orcid.org/0009-0008-6225-0730)
- Xiaojing Li (ORCID: https://orcid.org/0000-0002-9435-0866)
- Ying Shao
- Qing Du (ORCID: https://orcid.org/0000-0002-4349-5088)
- Qiuyun Gu
- Shiyu Gao (ORCID: https://orcid.org/0009-0007-8116-2640)
Institutions
- Shanghai Jiao Tong University (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Shanghai First People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fnut.2025.1675535
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China