Effects of aerobic treadmill exercise on the bone turnover in obese male mice
These findings are mainly related to the inhibition of the WNT signaling pathway and the dysregulation of adipokines. Aerobic exercise can effectively reduce the body weight of obese male mice and alleviate abnormalities in glucose and lipid metabolism. To some extent, it also alleviates the inhibition effect of obesity on WNT pathway signaling, promotes bone formation, and inhibits bone resorption.
Authors
- Bo Gao (ORCID: https://orcid.org/0000-0003-3599-5055)
- Limei Zhang (ORCID: https://orcid.org/0000-0003-0758-681X)
- Lingli Zhang (ORCID: https://orcid.org/0000-0003-3832-4046)
- Yuxiang Du (ORCID: https://orcid.org/0009-0005-0725-0939)
- Haiqi Lin
- Guanghua Liu
Institutions
- South China Normal University (CN)
- Shanghai University of Sport (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fcell.2025.1650496
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00