Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus
The present study provided new data on the location of SSTR in the human lung: notably, all types of receptor were found in the parasympathetic nerve ganglia of the bronchial wall. We suggest that the activation of prejunctional SSTR<sub>3</sub> and SSTR<sub>5</sub> receptors potentiates cholinergic-nerve-mediated contraction induced by EFS in human bronchi.
Authors
- Stanislas Grassin‐Delyle (ORCID: https://orcid.org/0000-0001-5747-4432)
- Camille Roquencourt (ORCID: https://orcid.org/0000-0002-0218-6086)
- Marion Brollo (ORCID: https://orcid.org/0009-0009-5991-4011)
- Hélène Salvator (ORCID: https://orcid.org/0000-0001-9294-5340)
- Matthieu Glorion (ORCID: https://orcid.org/0000-0002-3233-860X)
- Élisabeth Longchampt
- P. Devillier
- Isabelle Miguet-Besson
Institutions
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- Hôpital Foch (FR)
- Infection et inflammation (FR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fphar.2025.1677183
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00