Role of heparin-induced HGF release in the acute phase of STEMI
This study demonstrates that heparin induces a rapid and substantial increase in circulating HGF in STEMI patients, potentially mediating cardioprotection during reperfusion. These findings suggest that comedications like heparin may confound cardioprotective trials and should be considered in future translational strategies.
Authors
- Laura Mechtouff (ORCID: https://orcid.org/0000-0001-9165-5763)
- C. Crola Da Silva
- T. Bochaton
- Simon Leboube
- Bruno Pillot (ORCID: https://orcid.org/0000-0002-1499-3299)
- G. Bidaux
- Hélène Thibault (ORCID: https://orcid.org/0000-0001-9784-0425)
- Alexandre Paccalet (ORCID: https://orcid.org/0000-0002-6331-562X)
- Florence Moulin (ORCID: https://orcid.org/0000-0002-8604-2564)
- Charles Le Brun
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Inserm (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition (FR)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fcvm.2025.1668882
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00