Mitomycin C-induced DNA double-strand breaks are enhanced by catalytical inactivation of DNA polymerase κ in mice
Polk plays a systemic role in mitigating MMC-induced DSBs, likely through both DNA replication-dependent and -independent mechanisms. Furthermore, Polk appears to protect against DSBs caused by endogenous mutagens in some organs such as the adrenal cortex, prostate, and retina.
Authors
- Kaori Matsuzaki (ORCID: https://orcid.org/0000-0003-0545-5541)
- Kaoru Matsumoto (ORCID: https://orcid.org/0000-0001-6227-3045)
- Kou‐ichi Jishage
- Hiromi Tateishi
- Kei‐ichi Sugiyama
- Masayuki Mishima (ORCID: https://orcid.org/0000-0002-3024-3869)
- Kenichi Masumura (ORCID: https://orcid.org/0000-0002-7907-164X)
- Petr Grúz (ORCID: https://orcid.org/0000-0003-4627-6611)
- Akira Takeiri (ORCID: https://orcid.org/0000-0002-5230-3850)
- Saori Matsuo
- Akira Sassa (ORCID: https://orcid.org/0000-0003-2454-0223)
- Naoko Niimi (ORCID: https://orcid.org/0000-0001-9222-1596)
- Naoko Wada (ORCID: https://orcid.org/0000-0001-6916-3025)
- Shigeki Motoyama
- Kenji Tanaka
- Takehiko Nohmi
- Etsuko Fujii-Takeiri
Institutions
- Chiba University (JP)
- Yokohama University of Pharmacy (JP)
- Tokyo Institute of Psychiatry (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- National Institute of Occupational Safety and Health (JP)
- Chugai Pharma (United States) (US)
- Pola Chemical Industries (Japan) (JP)
- National Institute of Health Sciences (JP)
Publication Details
- Journal
- Genes and Environment
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s41021-025-00343-x
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chugai Pharmaceutical