The role of 4DCT in the localization of parathyroid adenomas in primary hyperparathyroidism: a retrospective cohort study
Adding 4D-CT to US and sestamibi scintigraphy (SeS) significantly improves the detection of parathyroid adenomas over US and SeS alone. 4D-CT provides the highest agreement with surgical findings, improving surgical planning. 4D-CT effectively identifies adenomas in ectopic locations, often missed by US and SeS. The most common cause of false-negative 4D-CT results is adenoma adherence to the thyroid, misread as thyroid tissue. Negative imaging results across all modalities warrant cautious interpretation.
Authors
- Jeroen Meulemans (ORCID: https://orcid.org/0000-0003-1761-1222)
- Scott Klerkx (ORCID: https://orcid.org/0000-0002-5117-2369)
- Janne Vignero (ORCID: https://orcid.org/0000-0003-0637-6618)
- Brigitte Decallonne (ORCID: https://orcid.org/0000-0003-4153-4757)
- Lennert Boeckxstaens
- Lesley Cockmartin
- Robert Hermans (ORCID: https://orcid.org/0000-0002-9935-5543)
Institutions
- Universitair Ziekenhuis Leuven (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Insights into Imaging
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s13244-025-02133-z
- Citations
- 1
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.43