Mild cross-coupling of tertiary alkoxides with aryl chlorides enabled by a shelf-stable methylnaphthyl palladium NHC complex
The catalytic coupling of tertiary alkoxides with aryl halides has a high energetic barrier, which makes KO<i>t</i>Bu an advantageous base in cross-couplings. A palladium methylnaphthyl (MeNAP) catalyst bearing the IPent<sup>Cl</sup> ligand was found to promote this C-O coupling with high efficiency, enabling the synthesis of aryl <i>t</i>-alkyl ethers from abundant aryl chlorides.
Authors
- Ralf Fleischer
- Angelino Doppiu (ORCID: https://orcid.org/0009-0002-0965-5444)
- Nikolaos V. Tzouras (ORCID: https://orcid.org/0000-0003-1718-0207)
- Sourav Manna (ORCID: https://orcid.org/0000-0003-3018-0949)
- Lukas J. Gooßen (ORCID: https://orcid.org/0000-0002-2547-3037)
- Pierpaolo Satta (ORCID: https://orcid.org/0000-0001-6180-9397)
Institutions
- Umicore (Belgium) (BE)
- Umicore (Germany) (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05726d
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft