Proteome-wide Mendelian randomization and colocalization analysis uncovers druggable targets for lung cancer across multiple phenotypes and complications
This study reveals causal proteins for various lung cancer phenotypes and complications, emphasizing causal pathways and potential therapeutic targets for lung cancer and providing new insights into its etiology, prevention, treatment, and therapy.
Authors
- Yunpeng Chen (ORCID: https://orcid.org/0000-0002-9830-8980)
- Lijuan Yao
- Peng Zhang (ORCID: https://orcid.org/0000-0002-6881-9800)
- Xiaohong Dai
- Tao Gao (ORCID: https://orcid.org/0000-0002-0789-9608)
- Zhihong Qin (ORCID: https://orcid.org/0000-0002-2410-9305)
- Junguo Zhang (ORCID: https://orcid.org/0000-0001-8263-1786)
- Qing Wang (ORCID: https://orcid.org/0000-0002-3449-0242)
Institutions
- Beijing Fengtai Hospital (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1007/s12672-025-03910-4
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00