Serum IgG N-glycans act as serum biomarkers for differentiation of cold and heat pattern in rheumatoid arthritis
This glycomics-based approach identified and validated novel N-glycan biomarkers associated with both RA diagnosis and TCM syndrome differentiation. The combination of these N-glycan biomarkers and our diagnostic model offers a promising strategy for integrating modern diagnostic techniques with TCM classification in RA management.
Authors
- Zishao Zhong
- Jiaqi Wu (ORCID: https://orcid.org/0000-0002-9367-675X)
- Hudan Pan (ORCID: https://orcid.org/0000-0002-7287-9718)
- Yao Xiao (ORCID: https://orcid.org/0000-0003-0062-9813)
- Liang Liu (ORCID: https://orcid.org/0000-0001-7556-4810)
- Yilin Wang (ORCID: https://orcid.org/0009-0007-3516-993X)
- Jingrong Wang (ORCID: https://orcid.org/0000-0003-1860-6740)
- Yu Lai
- Hao Yu (ORCID: https://orcid.org/0000-0001-9119-6114)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- University of Macau (MO)
- Integrated Chinese Medicine (China) (HK)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s13020-025-01246-3
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangzhou Municipal Science and Technology Bureau
- National Key Research and Development Program of China