Endothelial SRSF1 Promotes Ischemia-Induced Angiogenesis via ATF3-KLF2-S1PR1 Pathway
Our findings identified SRSF1 as a novel regulator of ischemia-induced angiogenesis that enhances endothelial angiogenic functions by regulating the ATF3-KLF2-S1PR1 pathway. These results suggest that modulation of endothelial SRSF1 may represent a promising therapeutic approach for treating ischemic vascular diseases.
Authors
- Ning Xie (ORCID: https://orcid.org/0000-0002-6559-2997)
- Chun-Mei Cao (ORCID: https://orcid.org/0000-0002-7162-3104)
- Lixuan Huang (ORCID: https://orcid.org/0000-0001-5853-4265)
- Qinghua Cui (ORCID: https://orcid.org/0000-0003-3018-5221)
- Yingjiao Ju (ORCID: https://orcid.org/0000-0002-3842-850X)
- X Wang (ORCID: https://orcid.org/0000-0003-4559-5450)
- Weiwei An (ORCID: https://orcid.org/0009-0006-0788-3629)
- Rilei Dai (ORCID: https://orcid.org/0000-0003-1218-2174)
- Le Gao (ORCID: https://orcid.org/0000-0003-4852-8894)
- Zhenyan Li (ORCID: https://orcid.org/0000-0002-0319-2832)
- Jingchen Li (ORCID: https://orcid.org/0000-0003-2371-5095)
- Yangli Liu (ORCID: https://orcid.org/0000-0002-4081-8291)
- Bing Hua (ORCID: https://orcid.org/0000-0002-0921-7906)
- Yang Li (ORCID: https://orcid.org/0000-0002-5777-8329)
- Wenting Zhu (ORCID: https://orcid.org/0000-0001-8680-7910)
- Jing Guo (ORCID: https://orcid.org/0009-0002-9728-2915)
- Kun Zhu (ORCID: https://orcid.org/0000-0002-4499-1905)
- Mingyang Li (ORCID: https://orcid.org/0000-0003-0354-1542)
- Kuo Bi (ORCID: https://orcid.org/0009-0005-9127-6583)
- Zhiheng Lin (ORCID: https://orcid.org/0009-0002-6963-0011)
- Yufei Wang (ORCID: https://orcid.org/0009-0000-6337-5211)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Friendship Hospital (CN)
- Children's Hospital of Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1161/circresaha.125.326391
- Citations
- 2
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 1.61